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KMID : 0356719960120020269
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Journal of the Korean Society of Coloproctology
1996 Volume.12 No. 2 p.269 ~ p.276
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Effects of Perioperative Blood Transfusion on the Prognosis of Colorectal Cancer
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Lee Ryung-Ah
Kim Kwang-Ho
Park Eung-Bum
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Abstract
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The immunosuppressive effect of blood transfusion was first recognized in patients undergoing renal transplantation. Recent interest has centered on the effect of transfusion in patients with various malignancies, especially colorectal cancer. Some studies have shown that blood transfusion has a detrimental effect, incereasing the risk of recurrence and decreasing survival, whereas others failed to confirm these findings. To confirm the association, a retrospective study was conducted on 138 patients undergoing curative resection for colorectal carcinoma. Recurrence was diagnosed in
49(63.6%) of those who had received blood transfusion and 21 (34.4%) of those who had not(p<0.05). There was no difference of recurrence rate between transfused and untransfused patients in the moderately differentiated tumors. In the well and poorly differentiated tumors, however, there was a significant increase in recurrence rate among those who had been transfused. Recurrence rates were no different according to the amount of transfusion. The 5 year survival rates were 35.3% in patients who had received transfusion and 55% in patients who had not(p<0.05). These results suggest that the risk of recurrence following curative resection for colorectal cancer is increased by perioperative blood transfusion.
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KEYWORD
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Transfusion, Colorectal Neoplasms
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